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- 1 : Onco-dermatology and Therapies
- 10 : HLA-G immune checkpoint in Oncology and Transplantation
- 11 : T cell immunity in cancers and infectious diseases
- 2 : Skin Immunity and Inflammation
- 3 : Endothelium, Inflammation et Allogenicity
- 4 : Immune responses in the immunocompromised host: Tolerance versus GVHD
- 5 : Lymphocyte development and lymphoid disorders
- 6 : Pathophysiology of breast cancer
- 7 : Stem Cells Biotechnologies
- 8 : Physics of the cytoskeleton and morphogenesis
- 9 : Human Systems Immunology & Inflammatory Networks Team
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Posts
Event
- Fondation ARC et Sébastien Jauliac : Cancer du sein
- Isabelle André : “T-cell progenitors, a new therpeutic tool”
- Pierre Bost : “Single-cell and spatial approaches to dissect viral infections : from bench to analysis”
- Véronique Baud : “The alternative RelB NF-kB activation and metabolic reprogramming in cancer cells”
News
- Acto-myosin network geometry defines centrosome position
- Day of Immunology 2021 : Young researchers are talking with kids about our amazing immune system !
- Edgardo D. Carosella présente l’ouvrage “Sous le sceau du secret. Les plis cachetés de l’Académie des sciences”
- Fondation ARC et Sébastien Jauliac : Cancer du sein
- François Desgrandchamps receives the 2020 Jean Bernard Prize from the FRM
- HIPI Team 9 engaged in an ambitious partnership with two french biotech companies on modeling the function of anti-IL-2 receptor therapeutic antibodies
- Hommage au Dr Gérard Chaouat
- La FHU APOLO, coordonnée par le professeur Carmen Lefaucheur, met en ligne son nouveau site
- Martine Bagot and Armand Bensussan are rewarded for their research and receive the Galien Prize 2020 on the 18th of December
- NOMINATIONS au sein de HIPI à l’Hôpital Saint-Louis (FR)
- Sébastien Jauliac is awarded from the Gefluc association
- Two scholarships from the HOB doctoral school in 2020
- Vassili Soumelis has received the Lucien Tartois Prize
News : Team 10
News : Team 11
- Dr. Tonnerre’s team will investigate how the dendritic cell plasticity can modulate antigen-specific T cell functions in human
- How DCs can awaken the force in Influenza-specific memory CD4+ T cells
- Impact of checkpoint blockade immunotherapy on the immune response to BCG in patients with bladder cancer
News : Team 7
Publications
- 18F-FDG labelling of hematopoietic stem cells: Dynamic study of bone marrow homing by PET-CT imaging and impact on cell functionality
- A clinical-grade acellular matrix for esophageal replacement
- A computational workflow for the detection of candidate diagnostic biomarkers of Kawasaki disease using time-series gene expression data
- A multivariate modeling framework to quantify immune checkpoint context-dependent stimulation on T cells
- A multivariate Th17 metagene for prognostic stratification in T cell non-inflamed triple negative breast cancer
- A Quantitative Multivariate Model of Human Dendritic Cell-T Helper Cell Communication
- A refined molecular taxonomy of breast cancer
- A Systematic Review of Immunotherapy in Urologic Cancer: Evolving Roles for Targeting of CTLA-4, PD-1/PD-L1, and HLA-G
- A targeted genomic alteration analysis predicts survival of melanoma patients under BRAF inhibitors
- Abolishing serum interference in detection of HLA antibodies: Who, How, When and Why?
- Actin filaments regulate microtubule growth at the centrosome
- Actin network architecture determines myosin motor activity
- Actin-Network Architecture Regulates Microtubule Dynamics
- Acto-myosin network geometry defines centrosome position
- Acute kidney injury in critically ill patients with COVID-19
- Adaptive immune cell responses as therapeutic targets in antibody-mediated organ rejection
- Adjustment of dendritic cells to the breast-cancer microenvironment is subset specific
- Age-Associated Decrease of the Histone Methyltransferase SUV39H1 in HSC Perturbs Heterochromatin and B Lymphoid Differentiation
- Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT
- Applications of Non-Coding RNAs in Multiple Myeloma Patients.
- Archetype Analysis Identifies Distinct Profiles in Renal Transplant Recipients with Transplant Glomerulopathy Associated with Allograft Survival
- Architecture and connectivity govern actin network contractility
- Are the immune properties of mesenchymal stem cells from Wharton Jelly maintained during chondrogenic differentiation?
- Atypical BRAF and NRAS Mutations in Mucosal Melanoma
- Azithromycin promotes relapse by disrupting immune and metabolic networks after allogeneic stem cell transplantation.
- Baseline Genomic Features in BRAFV600-Mutated Metastatic Melanoma Patients Treated with BRAF Inhibitor + MEK Inhibitor in Routine Care
- Bi 38-3 is a novel CD38/CD3 bispecific T-cell engager with low toxicities for the treatment of multiple myeloma
- Biallelic deletion of 1p32 defines ultra-high-risk myeloma, but monoallelic del(1p32) remains a strong prognostic factor.
- Biodistribution of allogenic umbilical cord-derived mesenchymal stromal cells after fetal repair of myelomeningocele in an ovine model
- Breast Cancer Cell-Derived GM-CSF Licenses Regulatory Th2 Induction by Plasmacytoid Predendritic Cells in Aggressive Disease Subtypes
- CAR-T cells derived from multiple myeloma patients at diagnosis have improved cytotoxic functions compared to those produced at relapse or following daratumumab treatment.
- Carfilzomib, venetoclax and dexamethasone for relapsed/refractory multiple myeloma.
- CD147 Is a Promising Target of Tumor Progression and a Prognostic Biomarker
- CD4+CD8+ T-Lymphocytes in Xenogeneic and Human Graft-versus-Host Disease.
- CD8+PD-1-ILT2+ T Cells Are an Intratumoral Cytotoxic Population Selectively Inhibited by the Immune-Checkpoint HLA-G
- Cell shape and contractility regulate ciliogenesis in cell cycle arrested cells
- Cell therapy for prenatal repair of myelomeningocele: A systematic review
- Centrosome centering and decentering by microtubule network rearrangement
- Circadian Clock Genes Modulate Human Bone Marrow Mesenchymal Stem Cell Differentiation, Migration and Cell Cycle
- Circulating T cell profiles associate with enterotype signatures underlying hematological malignancy relapses.
- Circumferential Esophageal Replacement by a Tissue-engineered Substitute Using Mesenchymal Stem Cells: An Experimental Study in Mini Pigs
- Circumferential esophageal replacement using a tube-shaped tissue-engineered substitute: An experimental study in minipigs
- Clinical Applications of Non-Coding RNAs in Cancer
- Combinatorial code governing cellular responses to complex stimuli
- Combinatorial flexibility of cytokine function during human T helper cell differentiation
- Comprehensive landscape of immune-checkpoints uncovered in clear cell renal cell carcinoma reveals new and emerging therapeutic targets
- Concomitant loss of regulatory T and B cells is a distinguishing immune feature of antibody-mediated rejection in kidney transplantation
- Context-Dependent Effects Explain Divergent Prognostic Roles of Tregs in Cancer
- Convergence of microengineering and cellular self-organization towards functional tissue manufacturing
- Coordinated Circulating T Follicular Helper and Activated B Cell Responses Underlie the Onset of Antibody-Mediated Rejection in Kidney Transplantation
- CpG-Activated Regulatory B-Cell Progenitors Alleviate Murine Graft-Versus-Host-Disease
- Current anti-myeloma therapies in renal manifestations of monoclonal light chain-associated Fanconi syndrome: a retrospective series of 49 patients
- Development of chimeric antigen receptors for multiple myeloma
- Development of extracellular vesicle-based medicinal products: a position paper of the group “Extracellular Vesicle translatiOn to clinicaL perspectiVEs – EVOLVE France
- Differentiation of exhausted CD8 T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory.
- Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory
- Dissection of intercellular communication using the transcriptome-based framework ICELLNET
- Distinct subsets of multi-lymphoid progenitors support ontogeny-related changes in human lymphopoiesis.
- Diversification of human plasmacytoid predendritic cells in response to a single stimulus
- Donor-specific antibodies are not only directed against HLA-DR: minding your Ps and Qs
- Dual chimeric antigen receptor T cells targeting CD38 and SLAMF7 with independent signalling demonstrate preclinical efficacy and safety in Multiple Myeloma.
- Dual role of the ddx5/ddx17 RNA helicases in the control of the pro-migratory NFAT5 transcription factor
- Early assessment with 18F-fluorodeoxyglucose positron emission tomography/computed tomography can help predict the outcome of neoadjuvant chemotherapy in triple negative breast cancer
- Editorial: Alloimmune response From Regenerative Medicine
- Effect of Azithromycin on Airflow Decline-Free Survival After Allogeneic Hematopoietic Stem Cell Transplant: The ALLOZITHRO Randomized Clinical Trial
- Effect of brincidofovir on adenovirus and A549 cells transcriptome profiles
- Efficient Therapeutic Delivery by a Novel Cell-Penetrating Peptide Derived from Acinus
- Endothelial CD34 expression and regulation of immune cell response in-vitro
- Endothelial cell amplification of regulatory T cells is differentially modified by immuno- suppressors and intravenous immunoglobulin
- Endothelial cell, myeloid and adaptive immune responses in SARS-CoV-2 infection
- Endothelial Cells Activated by Extracellular Histones Promote Foxp3+ Suppressive Treg Cells In Vitro
- Endothelial Cells Activated by Tumor Lysis Syndrome and AKI: Beyond Crystal MechanismsHistones Promote Foxp3+ Suppressive Treg Cells In Vitro
- Endothelial cells: major players in acute myeloid leukaemia
- Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans
- Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans.
- Evolution of the innate and adaptive immune response in women with acute Zika virus infection
- Expansion of circulating CD49b+LAG3+ type 1 regulatory T (Tr1) cells in human chronic graft-versus-host disease.
- Expansion of Circulating CD49b+LAG3+ Type 1 Regulatory T Cells in Human Chronic Graft-Versus-Host Disease
- Extracellular vesicles from human cardiovascular progenitors triggers a reapartive immune response in infracted hearts
- Extracellular vesicles produced by NFAT3-expressing cells hinder tumor growth and metastatic dissemination
- Extracellular Vesicles Released by Allogeneic Human Cardiac Stem/Progenitor Cells as Part of their Therapeutic Benefit
- FGF2 Induces Resistance to Nilotinib through MAPK Pathway Activation in KIT Mutated Melanoma
- Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer
- Genetic diversity of the human adenovirus species C DNA polymerase
- Hematopoietic progenitors polarize in contact with bone marrow stromal cells in response to SDF1
- Hematopoietic Stem Cell Aging and Malignant Hemopathies
- Hepatitis-B virus: replication cycle, targets, and antiviral approaches.
- Heterogeneous functions of Perinatal Mesenchymal Stromal Cells require a pre-selection before their banking for clinical use
- Histone methyltransferase MMSET promotes AID-mediated DNA breaks at the donor switch region during class switch recombination
- HLA and lung transplantation
- HLA class II antibody activation of endothelial cells promotes Th17 and disrupts regulatory T lymphocyte expansion
- HLA-DQ alloantibodies directly activate the endothelium and compromise differentiation of FoxP3hi regulatory T lymphocytes
- HLA-DQ alloantibodies directly activate the endothelium and compromise dif- ferentiation of FoxP3high regulatory T lymphocytes
- HLA-G: an Immune Checkpoint Molecule
- HLA-G/LILRBs: A Cancer Immunotherapy Challenge
- Human blood BDCA-1 dendritic cells differentiate into Langerhans-like cells with thymic stromal lymphopoietin and TGF-β
- Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report
- Human endothelial cells generate Th17 and regulatory T cells under inflammatory conditions.
- Human keratinocytes inhibit CD4+ T-cell proliferation through TGFB1 secretion and surface expression of HLA-G1 and PD-L1 immune checkpoints
- Human Lymphopoiesis Proceeds Along Independent CD127- and CD127+ Development Pathways
- Human MAIT cells are devoid of alloreactive potential: prompting their use as universal cells for adoptive immune therapy.
- Hypoxia inducible factor-1 mediates the expression of the immune checkpoint HLA-G in glioma cells through hypoxia response element located in exon 2
- Identification of CD39 as a Marker for the Circulating Malignant T-Cell Clone of Sézary Syndrome Patients
- Identification of novel human monocyte subsets and evidence for phenotypic groups defi- ned by interindividuel variations of expression of adhesion molecules
- Ifosfamide and etoposide in advanced-stage, relapsed or refractory primary cutaneous T-cell lymphomas
- ILC2-modulated T-cell-to-MDSC balance is associated with bladder cancer recurrence
- Immune Consequences of Endothelial Cells’ Activation and Dysfunction During Sepsis
- Immune landscape after allo-HSCT: TIGIT- and CD161-expressing CD4 T cells are associated with subsequent leukemia relapse.
- Immunity to commensal skin fungi promotes psoriasiform skin inflammation
- Impact of macrolide therapy in critically ill patients with acute respiratory failure: a desirability of outcome ranking analysis to investigate the OUTCOMEREA database
- In utero treatment of myelomeningocele with allogenic umbilical cord-derived mesenchymal stromal cells in an ovine model
- In vitro and in vivo evaluation of cord blood hematopoietic stem and progenitor cells amplified with glycosaminoglycan mimetic
- Increased expression of PD1 and CD39 on CD3+ CD4+ skin T cells in the elderly
- Inflammation Determines the Capacity of Allogenic Endothelial Cells to Regulate Human Treg Expansion
- Inflammatory Waldenström’s macroglobulinaemia: A French monocentric retrospective study of 67 patients.
- iNKT and memory B-cell alterations in HHV-8 multicentric Castleman disease
- Insights from integrating clinical and preclinical studies advance understanding of graft-versus-host disease
- Interest and limits of assessing acute kidney injury in administrative dataset
- Intratumor heterogeneity of immune checkpoints in primary renal cell cancer: Focus on HLA-G/ILT2/ILT4
- IPH4102, a first-in-class anti-KIR3DL2 monoclonal antibody, in patients with relapsed or refractory cutaneous T-cell lymphoma: an international, first-in-human, open-label, phase 1 trial
- Kaposi sarcoma-associated herpesvirus/human herpesvirus 8-associated lymphoproliferative disorders
- Lattice defects induce microtubule self-renewal
- Ligand-receptor dissociated expression explains high TSLP without prognostic impact in human primary head and neck squamous cell carcinoma
- Lipocalin 2, the TNF-like receptor TWEAKR and its ligand TWEAK act downstream of NFAT1 to regulate breast cancer cell invasion
- MB4-2 breakpoint in MMSET combined with del(17p) defines a subset of t(4;14) multiple myeloma with very poor prognosis
- MDA5(+) Dermatomyositis Is Associated with Stronger Skin Type I – Interferon Transcriptomic Signature with Upregulation of IFN-κ Transcript
- Metabolic reprogramming by Zika virus provokes inflammation in human placenta
- Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites
- Microenvironment tailors nTreg structure and function
- Microtubule stabilization drives 3D centrosome migration to initiate primary ciliogenesis
- Microtubules control nuclear shape and gene expression during early stages of hematopoietic differentiation
- Microtubules self-repair in response to mechanical stress
- Milestones in acute GVHD pathophysiology.
- MMP2 as an independent prognostic stratifier in oral cavity cancers
- Modeling the Th17 and Tregs Paradigm: Implications for Cancer Immunotherapy
- Molecular apocrine breast cancers are aggressive estrogen receptor negative tumors overexpressing either HER2 or GCDFP15
- Multiple Roles of the Interleukin IL-17 Members in Breast Cancer and Beyond
- Network heterogeneity regulates steering in actin-based motility
- Neutrophils cause a « NET » increase in skin allo- graft allogenicity
- Next generation sequencing in myeloid neoplasm-associated Sweet’s syndrome demonstrates clonal relation between malignant cells and skin-infiltrating neutrophils
- NFAT3 transcription factor inhibits breast cancer cell motility by targeting the Lipocalin 2 gene
- Non-HLA agonistic anti-angiotensin II type 1 receptor antibodies induce a distinctive phenotype of antibody-mediated rejection in kidney transplant recipients
- Novel landscape of HLA-G isoforms expressed in clear cell renal cell carcinoma patients
- Nucleation geometry governs ordered actin networks structures
- Oncogenic TRIM37 links chemoresistance and metastatic fate in triple-negative breast cancer
- Ontogeny of human mucosal-associated invariant T cells and related T cell subsets
- PD-1 mediates functional exhaustion of activated NK cells in patients with Kaposi sarcoma
- PD-L1 and ICOSL discriminate human Secretory and Helper dendritic cells in cancer, allergy and autoimmunity
- Phenotype and function of HBV-specific T cells is determined by the targeted epitope in addition to the stage of infection
- Polarity Reversal by Centrosome Repositioning Primes Cell Scattering during Epithelial-to-Mesenchymal Transition
- Prediction of non-muscle-invasive bladder cancer recurrence by measurement of checkpoint HLAG’s receptor ILT2 on peripheral CD8+ T cells
- Prediction system for risk of allograft loss in patients receiving kidney transplants: international derivation and vali- dation study
- Prognosis of hyperviscosity syndrome in newly diagnosed multiple myeloma in modern-era therapy: A real-life study.
- Prognostic Impact of Stromal Immune Infiltration before and after Neoadjuvant Chemotherapy (NAC) in Triple Negative Inflammatory Breast Cancers (TNIBC) Treated with Dose-Dense Dose-Intense NAC
- Prophylactic and therapeutic antileukemic effects induced by the AAC-11-derived Peptide RT53
- Randomized Trial Comparing Double Versus Triple Bortezomib-Based Regimen in Patients With Multiple Myeloma and Acute Kidney Injury Due to Cast Nephropathy
- Real-world characteristics of T-cell apheresis and clinical response to tisagenlecleucel in B-cell lymphoma.
- Recommended Treatment for Antibody-mediated Rejection After Kidney Transplantation: the 2019 Expert Consensus From the Transplantion Society Working Group
- Response to treatment and long-term outcomes in kidney transplant recipients with acute T cell-mediated rejection
- Role of HLA-G as a Predictive Marker of Low Risk of Chronic Rejection in Lung Transplant Recipients: A Clinical Prospective Study
- Ruxolitinib for Glucocorticoid-Refractory Acute Graft-versus-Host Disease.
- Safety and efficacy of eculizumab for the prevention of antibody-mediated rejection after decea- sed-donor kidney transplantation in patients with preformed donor-specific antibodies
- Safety and efficacy of eculizumab in the prevention of antibody-mediated rejection in living-donor kidney transplant recipients requiring desensitization therapy: A randomized trial
- SARS-CoV-2 induces human plasmacytoid predendritic cell diversification via UNC93B and IRAK4
- Self-organization and culture of Mesenchymal Stem Cell spheroids in acoustic levitation
- Self-Organogenesis from 2D Micropatterns to 3D Biomimetic Biliary Trees
- Self-repair promotes microtubule rescue
- Single-cell atlas of the liver myeloid compartment before and after cure of chronic viral hepatitis.
- Single-cell RNA sequencing of blood antigen-presenting cells in severe COVID-19 reveals multi-process defects in antiviral immunity
- Spatial organization of the extra-cellular matrix regulates cell-cell junction positioning
- Study of gene expression alteration in male androgenetic alopecia: evidence of predominant molecular signalling pathways
- System level immune monitoring reveals new pathophysiological features in hepatitis-associated aplastic anemia.
- Systems analysis of human T helper17 cell differentiation uncovers distinct time-regulated transcriptional modules
- T cell antigenicity and immunogenicity of allogeneic exosomes
- T-bet+CD27+CD21- B cells poised for plasma cell differentiation during antibody-mediated rejection of kidney transplants
- Targeting T Follicular Helper Cells To Control Humoral Allogeneic Immunity
- TH cell diversity and response to dupilumab in patients with atopic dermatitis
- The centrosome is an actin-organizing center
- The eukaryotic gut virome in hematopoietic stem cell transplantation: new clues in enteric graft-versus-host disease
- The first world cell race
- The genetic diversity within the 1.4 kb HLA-G 5′ upstream regulatory region moderately impacts on cellular microenvironment responses
- The immune-checkpoint HLA-G/ILT4 is involved in the regulation of VEGF expression in clear cell renal cell carcinoma
- The long non-coding RNA CRNDE regulates growth of multiple myeloma cells via an effect on IL6 signalling
- The multifaceted immune regulation of bladder cancer
- The NFAT3/RERG complex in luminal breast cancers is required to inhibit cell invasion and may be correlated with an absence of axillary lymph nodes colonization
- The PD-1 Axis Enforces an Anatomical Segregation of CTL Activity that Creates Tumor Niches after Allogeneic Hematopoietic Stem Cell Transplantation
- The role of NFAT transcription factors in integrin-mediated carcinoma invasion
- The Role of the Endothelium during Antibody-Mediated Rejection: From Victim to Accomplice
- The Sec61 translocon is a therapeutic vulnerability in multiple myeloma.
- The size-speed-force relationship governs migratory cell response to tumorigenic factors
- The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection
- Thymic stromal lymphopoietin links keratinocytes and dendritic cell-derived IL-23 in patients with psoriasis
- TLR1/2 orchestrate human plasmacytoid predendritic cell response to gram+ bacteria
- TNFA, ANXA11 and BTNL2 Polymorphisms in CVID Patients with Granulomatous Disease
- Toward practical transparent verifiable and long-term reproducible research using Guix.
- Transcriptome-based identification of novel endotypes in adult atopic dermatitis
- Transplantation of Human Embryonic Stem Cell-Derived Cardiovascular Progenitors for Severe Ischemic Left Ventricular Dysfunction
- Transplantation of Human Embryonic Stem Cell-Derived Cardiovascular Progenitors for Severe Ischemic Left Ventricular Dysfunction
- Trends in 3D bioprinting for esophageal tissue repair and reconstruction
- Trogocytic intercellular membrane exchanges among hematological tumors
- TSLP-activated dendritic cells induce human T follicular helper cell differentiation through OX40-ligand
- Tubulin acetylation protects long-lived microtubules against mechanical aging
- Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis
- Understanding tumor lysis syndrome
- Urinary metabolites give new clues to kidney transplant tolerance