HUMAN SYSTEMS IMMUNOLOGY AND INFLAMMATORY NETWORKS
Pr. Vassili SOUMELIS
HIPI (U976) Director
Vassili received his MD from Paris Necker University, and was trained as a clinical hematologist in the Lyon academic Hospitals. He did his immunology training under the supervision of Yong-Jun Liu, in Dardilly, France (Schering-Plough Laboratory for Immunological Research), and Palo Alto, California (DNAX Research Institute). After being an assistant professor in clinical hematology at the Necker medical school, he moved to the Institut Curie and started his lab in 2004. He and his team moved to Hôpital St Louis and Université de Paris at the end of 2018. He has always been working on human immunology and human disease physiopathology. His long time interests include dendritic cell and pDC biology, cytokine networks, and tissue inflammation. In the past ten years, he and his team developed a strong expertise in bioinformatics, computational biology, and mathematical modeling. He is fascinated by the complexity of the immune system and living systems in general, and loves working in interdisciplinary and international environments. Besides medicine and biology, he loves mathematics, linguistics, philosophy, making cocktails and playing ping-pong.
Research Engineer Inserm IR1 Plateforme Engineer
PhD on acute inflammation obtained in June 1992 at University Paris 7 (Fac. Med X.-Bichat). Spend one year in Germany in Peter Heinrich’s Lab, working on IL-6, followed by two post-doc positions at Gustave-Roussy Institute. Permanent position at Inserm since 1999 obtained in the Laboratory of Pathology of the Saint-Louis Research Institute, working on animal models for 20 years. Headleader of a laser microdissection unit and founder of a national network dedicated to this technology since 2001. Inserm award in 2008. Teacher in Master 2 BCM of Paris University since 2014. Member of the CSHSCT of ADR Inserm Paris 7. Member of the CAP3 of Inserm.
Administration Team Manager
Having a Master in Business and Human Resource Management, Salima has worked since her graduation, within multinational and well-known organizations (IBM, United Nations, Curie Institute). During her experience, she has developed her expertise in HRM and project management. She is now coordinating all budget and HR matters of the team.
Arturo obtained his PhD at the University of Guanajuato, Mexico. During his PhD he analyzed the function of glycosyltransferases in human pathogenic fungi. He did his postdoctoral degree at the Institut Pasteur in Paris, focusing on the study of genes that are involved in the chlamydospore formation pathway in C. albicans. Currently, he coordinates the scientific and clinical aspects of the H2020 European Program “ImmunAID”.
Pierre earned his Ph.D. degree in immunology and immunogenetics from the university of Nantes, France. He subsequently joined the Massachusetts General Hospital and Harvard Medical School where he focused his research on human antigen-specific T cell responses in different settings of acute and chronic viral infections. Pierre completed postdoctoral training at Institut Pasteur in Paris, then joined the team to build on his previous experiences a translational research program to study antigen-specific T cell functions in human health and diseases.
Sara has a background in biotechnology and obtained her international master degrees in “Systems & Synthetic Biology” and “Genomics Informatics” at the University of Paris-Saclay. She has an engineer position at Institut national de la santé et de la recherche médicale-Inserm and she is working on H2020 European Commission project “ImmunAID” under the supervision of Pr. Vassili Soumelis.
Image Processing Engineer
Faezeh holds two Master’s degrees in Image Processing and Biomedical Engineering. After graduation, she spent a few years working as a medical research engineer, while having the opportunity to work in Switzerland, Germany and France. She joined the lab in 2018 as an engineer. Her current projects involve the research on tumor microenvironment by analyzing histopathology image datasets using Artificial Intelligence algorithms.
Melissa is currently a computational biologist who joined the lab in October 2019. She graduated in 2018 with a Msc in Genomics, Informatics, Mathematics for Health & Environment (GENIOMHE) from Paris Saclay University. During her master degree, she worked on the characterization of intra-tumour heterogeneity at the single cell level in Neuroblastoma and Myelodysplastic Syndroms. Currently, she works on the developpment of a patient classification model, along with collaborative projects with both academic and industrial partners on inflammatory diseases.
Alba studied Molecular Biochemistry in my sunny hometown, Málaga (Spain) and obtained my Master’s degree in Translational Medicine Research at Universidad Complutense de Madrid. After my internships in health research in Ulm (Germany) and Madrid, She tarted in the lab as an engineer assistant. She is currently a Cifre (Industrial Agreement of Training through Research) PhD student with Servier. Her research is focused on the characterization of T cell diversity in Diffuse Large B cell Lymphoma microenvironment.
After undergraduate studies in biology and chemistry, Léa specialized in immunology and immunotherapies at Université Pierre et Marie Curie in Paris. She made her internships in several places, in Montreal, Sao Paulo and New York, more and more focused on molecules involved in immunotherapies and T cells. During her PhD, she worked on human tumor and blood samples and focused on OX40L, a co-stimulatory immune checkpoint molecule with great interest in immunotherapies. Her thesis aims to decipher the OX40L context-dependent function on human T helper cell polarization.
Lucile has a background in Physics, Chemistry, and Life Sciences. After her studies at ESPCI Paris and a master of Life Sciences at Ecole Normale Supérieure, she joined the lab in 2019 for a master internship in bioinformatic working on cell-cell communication tool based of cell transcriptomics data. She is now doing her PhD in the lab, focusing on cytokine-mediated intercellular communication in the tumor microenvironment, both with bioinformatic and wet lab approaches.
Pr. Abdellatif TAZI
Head of Pulmonary service of Saint Louis hospital
Sarantis obtained his first university degree in Biology from the University of Athens, Greece. Then, he moved to Paris where he performed his Master and PhD. During his PhD at Necker hospital in Paris, he studied the immune regulatory role of newly described hematopoietic progenitor cells against two murine models of autoimmunity, T1D and EAE. After his PhD, he joined the team of Pr. Terry Strom at Harvard Medical School in Boston, USA, where he investigated the role of Innate Lymphoid cells and B regulatory cells in models of sterile inflammation and transplantation. He is currently a post-doc researcher in experimental immunology working on human Tfh differentiation and involvement of pDC in inflammatory settings.
After obtaining a Master’s degree in computational biology in 2014, Floriane joined the lab as an engineer working on RNA-sequencing analysis of tumor-infiltrating immune cells. Then, she continued with a PhD focused on dendritic cells and cell-cell communication in human breast cancer microenvironement. She is now working as a post-doc researcher studying immune cell heterogeneity in cancer using single-cell RNA-sequencing.
Maëva is a post-doctoral researcher in the fields of genomic and disease modelling. After graduating from the University of Bordeaux in BioInformatics, she spend one year in PaleoEvo team (INRA) to study gene duplications in the context of genome evolution. Then, she obtained a PhD from Paris Saclay University. During her PhD, she studied the genetic component of Rheumatoid Arthirits, specifically the contribution of rare variants, by analyzing WES.
Iris holds a Master’s degree in Mathematics and Applications with a specialization in Statistics. She joined the lab in 2019 as an engineer after completing her Master’s thesis in the UMR AgroParisTech/INRA MIA-Paris lab within the Statistics and Genome team. She participated to a project regarding the quantitative modelling of OX40 ligand context-dependent function on human T helper cell polarization and her current project in on the understanding of the tumor microenvironment by using classification algorithms and statistical modelling.
Fanny joined the lab in 2019 to investigate Lupus Nephritis pathophysiology, by studying immune cell and stromal cell compartments of the kidney at the single cell level. Previously, she has been working in the field of immuno-oncology in E. Tartour’s (Paris, France), and in C. Caux’s team (Lyon, France), after obtaining her Master’s degree in Gene Therapy and Vaccinology from the University of Toulouse, France.
After studying engineering sciences, Elise decided to work in the health field and started a PhD whose subject tackles onco-immunity: She is studying T cell functions in the tumor microenvironment, but with a bioinformatician approach. Therefore, She also works on methodological aspects regarding the analysis of the data I am looking at.
Lilith Faucheux has a Master degree in Statistics with a specialisation in biostatistics. She first joinned the lab for an intership in applied statistics in immunology in breast cancer. She is currently working on her PhD thesis, co-hosted by a clinical biostatistics lab. Her PhD focus is on identifying group structures in dataset with missing data in unsupervised, and semi-supervised settings.
Alain is a medical doctor, specialized in pediatrics. He practices at Jean Verdier hospital, APHP. He began his research in JL Casanova’s lab at IMAGINE institute studying monogenic predisposition to infectious disease. Currently, he joined the lab to develop a biological and computational classification of atopic dermatitis.
Justine is a pharmacist, from the industrial field. She joined the lab in 2018, to do a PhD in which she studies the human lymphoid stromal cell environment in both physiological and pathological conditions.
Camille obtained my PhD from Nantes University working on a subset of cytotoxic dendritic cells. Her PhD was followed by several postdoctoral experiences in Oxford, Lille and London where she mainly specialized in Dendritic Cell biology, Cancer Immunology, Intestinal inflammation, Microbiota, Regulatory B cell Biology and Arthritis. She was Postdoctoral researcher studying the role of cytokines combination on human T helper cell differentiation.
Medical Resident in Clinical Hematology
Patent Engineer at ICOSA
Coline started in the lab as an engineer in 2013 and worked on human T follicular helper cell polarization by TSLP-activated dendritic cells. She continued with a Cifre (Industrial Agreement of Training through Research) PhD between the lab and Sanofi, working on deciphering human dendritic cell/T cell communication and studying T helper cell diversity in atopic dermatitis patients treated with Dupilumab. She is now working as a post-doc researcher on modeling OX40L context-dependent function on human T helper cell polarization.
Pediatric Emergency Physician in Robert-Debré Hospital