T CELL IMMUNITY IN CANCERS AND INFECTIONS DISEASES
Dr Pierre Tonnerre earned his Ph.D. in immunology and immunogenetics from the University of Nantes, France. He subsequently joined the Massachusetts General Hospital and Harvard Medical School where he focused his research on antigen-specific T cell responses to acute and chronic viral infections, in humans. Dr Tonnerre completed postdoctoral training at Institut Pasteur and Saint-Louis Hospital in Paris. He is a Marie Skłodowska-Curie fellow and a Laureate of the ATIP-Avenir program. His research group uses multi-omics approaches to investigate the heterogeneity and the plasticity of T cell responses to cancers and infectious diseases. Our aim is to develop novel immunotherapies and vaccination strategies.
Diane received a Master degree in Bioengineering from the university of Reims Champagne-Ardenne. Diane joined our team to be part of a consortium, regrouping academic experts and industrial partners, with the aim to dissect the mode of action of a therapeutic antibody directed against IL-2 receptor. To support the preclinical development of this antibody, Diane uses challenging in vitro co-culture systems of primary immune cell types to investigate how this antibody candidate alters the cross-talk between innate immune cells and T lymphocytes.
Margaux joined our lab in early 2022 for an internship, as part of her Master and Pharmacist degrees from University Paris Saclay. During her internship, Margaux worked on the design and development of a novel T cell therapy for the treatment of chronic hepatitis B virus infection (cHBV) and cHBV-induced hepatocellular carcinoma (HCC). Margaux will soon integrate a PhD program to pursue her research and make the proof of concept for this innovative T cell therapy.
Alba studied Molecular Biochemistry in her sunny hometown, Málaga (Spain) and obtained her Master’s degree in Translational Medicine Research at Universidad Complutense in Madrid. After several internships in health research at Ulm and Madrid, Alba joined our research unit as an assistant engineer. In 2020, she received a Cifre (Industrial Agreement of Training through Research) -PhD fellowship from Servier and ANRT. Using cutting edge technologies such as spectral flow cytometry and spatial transcriptomic, Alba aims at characterizing the T cell diversity in the Diffuse Large B Cell Lymphoma (DLBCL) microenvironment.
Fanny obtained her Master’s degree in Gene Therapy and Vaccinology from the University of Toulouse, France. Fanny performed several internships and worked during many years as a Research Engineer, conducting research programs in the field of Translational Immunology. She is now starting her Ph.D. training and she will employ challenging co-culture systems and multi-omics data analyses to investigate how human dendritic cells effectively re-activate antigen-specific memory T cells following Influenza re-exposure.
Paul graduated medical school in 2019 and is now a third-year resident in Urology in Paris, France. During his residentship, he participated in clinical studies in the field of bladder cancer. He is supplementing his training with a Master in Surgical Sciences and is joining our team for 1 year. He will take part in the research program on the impact of immune checkpoint inhibitors on BCG-induced immune responses in patients with bladder cancer.