Human Immunology, Pathophysiology, Immunotherapy
HIPI (“Human Immunology, Pathophysiology, Immunotherapy”) Unit 976 is an Inserm and Université de Paris research laboratory created in 2019. It is composed of ten teams including more than 200 members – academic researchers, clinicians, post-doctoral fellows, Ph.D students and an administrative staff. They are all located at Saint-Louis Hospital in Paris, France. HIPI laboratory belongs to the Saint-Louis Research Institute.
It is led by Jean-Christophe Bories, director. The administrative management of the unit is ensured by Hubert Grillot, Secretary General.
ONCO-DERMATOLOGY AND THERAPIES
Our team has expertise in skin cancers, with a special interest in cutaneous T cell lymphoma, melanoma and carcinoma.
ENDOTHELIUM, INFLAMMATION AND ALLOGENICITY
The endothelium has multiple functions in immune homeostasis and alterations of endothelial function can perturb immune function either by becoming a target of immune responses…
IMMUNE RESPONSES IN THE IMMUNO-COMPROMISED HOST: TOLERANCE VS GVHD
Our team focuses on the pathophysiological mechanisms of immune responses in immunocompromised subjects, mainly in the context of HSCT.
LYMPHOCYTE DEVELOPMENT AND LYMPHOID DISORDERS
Our research addresses fundamental questions related to the molecular mechanisms controlling the differentiation of hematopoietic stem cells towards lymphocytes and driving B cell oncogenesis…
PATHOPHYSIOLOGY OF BREAST CANCER
Our multidisciplinary team mainly focuses on the physiology and treatments of aggressive subgroups of breast cancers, with emphasis on the signaling pathways which impact their aggressiveness.
STEM CELLS BIOTECHNOLOGIES
Our multidisciplinary team is composed of engineers, biologists, physicians, surgeons and pharmacists. The team’s research axes relate to bioengineering, bioprinting technologies, and stem cell biology, with the aim of …
PHYSICS OF THE CYTOSKELETON AND MORPHOGENESIS
Our aim is to unravel the physical processes directing cytoskeleton self-organization. In particular we investigate the production and balance of mechanical forces in the networks.
HUMAN SYSTEMS IMMUNOLOGY AND INFLAMMATORY NETWORKS
Our team is an intercultural team coming from different countries and backgrounds. Our strength is due to the interdisciplinarity of our team members.
HLA-G AND OTHER IMMUNE CHECKPOINTS IN ONCOLOGY AND TRANSPLANTATION
Our team has expertise in immune tolerance mechanisms, with a special interest in those mediated by the checkpoint molecule HLA-G in oncology and transplantation.