IMMUNE RESPONSES IN THE IMMUNOCOMPROMISED HOST: TOLERANCE VERSUS GVHD
Prof. Sophie Caillat-Zucman is Head of the Saint-Louis Immunology Department, the largest in France with a unique activity in the field of organ and hematopoietic stem cell transplantation, and in CAR-T cell therapies. She obtained her MD in 1988 before being appointed as Assistant-Professor of Immunology (Université Paris V) and Head of the Histocompatibility Laboratory at Hopital Necker in 1992. Since 2011, she is Professor in Immunology at the Université Paris VII, and President of the French Biomedical Agency board of directors since 2015. Her main research interests pertained to HLAs or to NK cell receptors in autoimmune, infectious or malignant diseases. Her current research projects are focused on human Mucosal-associated invariant T (MAIT) cells and their usage in adoptive immune therapy.
Jérôme Le Goff is Professor of Virology at the University de Paris and in the Virology department in Saint-Louis hospital, Paris, France.
He obtained a PhD in Virology in the lab of Laurent Belec at the University of Paris Descartes where he studied interactions between HSV-2 and HIV. He then joined the laboratory of Francois Clavel (Inserm U941, Viral Evolution and pathogenesis). He did a post-doc in San Francisco in the Viral Diagnosis and Discovery Center led by Charles Chiu to analyze the gut Virome and its role in the enteric graft-versus host disease.
He finally joined our new research team to study how viruses interplay with the microbiome and host immunity to trigger graft-versus-host disease in hematopoietic stem cell transplant patients, and to investigate the pathogenesis of human adenoviruses and identify new drugs against these viruses.
David Michonneau is Associate Professor at the University de Paris and hematologist in Saint-Louis hospital. He graduated from the Ecole Normale Supérieure de Lyon in Immunology and Virology in 2005. He obtained a PhD in Immunology in the lab of Philippe Bousso at Pasteur Institute where he studied in vivo dynamic of immune response during Graft versus Host disease and Graft versus Leukemia Effect. He performed medical study in Lyon University and joined APHP in 2007 for his residency in hematology. He obtained a MD in 2012 on the role of donor B cells during GvHD after allogeneic HSCT. In 2015, he finally joined the unit of hematology and transplantation at Saint Louis hospital and our team to study immune system during the alloimmune response in GvL and GvHD. He is currently developing multi-omics approaches to improve our understanding of human immune system, based on mass cytometry, metabolomics and transcriptomics.
Mathieu graduated from the Ecole Supérieure de Biotechnologie de Strasbourg (ESBS) in 2009. He started to work in the HIV immunology field with Prof. Hendrik Streeck at the Ragon Institute of MGH, MIT and Harvard in Boston (USA), before joining the Pasteur Institute in Paris as a PhD student (Prof. F. Barré-Sinoussi’s lab). He worked there on acute HIV infection with Prof. L. Weiss and obtained his Ph.D. degree in immunology from the Université Paris VII. He then moved to Lausanne (Switzerland) to work for five years on cancer immune regulation topics with Dr. L. Derré at the Lausanne University Hospital. He finally joined our team to build his own research projects on immunoregulatory networks involved in the graft-versus-leukemia effect.
Saoussen Karray is CNRS researcher. She was a recipient of Fogarty international fellowship during her stay at University of California, Berkley. Her research is focused on the impact of cytokines in immune responses. Her early studies on IL-2/IL-4 antagonism in B cell responses have paved the way to the identification of the gamma chain common to several cytokine receptors. Later, she has developed FasL-KI mouse strain that enabled the understanding of the multiple roles of FasL in different inflammatory conditions. She is currently investigating the mechanisms underlying the distinct roles of FasL during GvHD.
Armelle obtained her PhD in immunology in the laboratory of Claire Hivroz at the Institut Curie, working on the role of cytoskeleton remodeling in T cell functions. Then she joined the lab of Philippe Bousso at the Institut Pasteur to study the mechanisms for the termination of T cell priming in vivo, and developed optogenetic approaches to manipulate T cell activation in time and space. To follow her research on T cell activation and functions, she moved to Hôpital Saint Louis to study MAIT T cells and their potential use in immunotherapies.
Nana studied Biotechnology at Lund University (Sweden) and Université Grenoble-Alpes. After a M2 internship on drug discovery in lung cancer (JL Coll’s lab, Institute for Advanced Biosciences in Grenoble), she started her PhD at the end of 2016. She is working on regulatory T cells in the context of allogeneic immune responses and GVHD, under the supervision of Prof. S. Caillat-Zucman and Prof. G. Socié.
Nicolas studied medicine in Paris from 2007 to 2013 and completed a clinical hematology residency, and a Master 2 in pathophysiology at the university of Tours in 2019 under the supervision of Prof. Gyan. He is particularly interested in exploring pathogenesis mechanisms that explain clinical observations. Nicolas is also keen on bioinformatics tools. He joined the team in 2019 for a PhD, exploring graft-versus-tumor effect in a translational study under the supervision of Dr. D. Michonneau and Prof. G. Socié.
Assistant Engineer/ Lab manager
After a bachelor in Industrial Microbiology, Marion first worked as a technician at the Kremlin-Bicêtre Hospital (lab of Prof. JF Delfraissy). In 2002, she joined the lab of Sophie Caillat-Zucman based over the years at Saint-Vincent-de-Paul, Necker, Robert Debré and Saint-Louis Hospitals in Paris. As long-standing cornerstone of the lab, she is now in charge of lab management duties as well as responsible for the FACS-sorting device.
Marie obtained her PhD in immunology in 2011 from the University Paris VII. She worked on the crosstalk between CD4 T cells and dendritic cells in the lab of Claire Hivroz and Sebastian Amigorena at Institut Curie. She then joined Sophie Caillat-Zucman’s lab in 2014 to work as a Research Engineer on MAIT cells ontogeny after birth and allo-HSCT. She is now focusing on the use of MAIT cells as universal CAR T-cell therapy.
Elise obtained a Master 2 in Molecular and Cellular Biology from the University Paris VII in 2015. She worked at the Institut Gustave Roussy to develop breast cancer cell models in Clara Nahmias’ lab. In 2018, she joined the lab as a research engineer to work with Jérôme Le Goff on drug discovery for the treatment of adenovirus infections following allogeneic stem cell transplantation.
Grégoire DE FREMONT
Prof. Gérard Socié is Head of the Hematology Transplantation department at Hôpital Saint-Louis in Paris. He is a leader in the field of hematopoietic stem-cell transplantation and graft-versus-host disease (GvHD). He obtained his MD in Hematology in 1988 and a PhD in Molecular Oncology in 1993 from the Université Paris VII. Since 2005, he is leading the largest Transplantation Program in France and one of the largest in Europe. He was head of the GVHD team in the Inserm unit U1160, before joining in 2019 the newly created HIPI Inserm unit at the Institut de Recherche Saint-Louis (IRSL) to co-lead the “Insight team” with Prof. Sophie Caillat-Zucman.
Member of the French Society of Hematology (SFH) since 1993, he was President of the Society from 2009 to 2017. Since 1994 he has been a member of the International Bone Marrow Transplant Registry (IBMTR) and chaired the Late Effects Committee since 1996. Also member of the European Bone Marrow Transplantation Group (EBMT), he chaired the Late Effects Working Group (2000-2006) and the Prospective Clinical Trials Committee (2005-2010). His main area of expertise in clinics and research is allogeneic stem cell transplantation with a particular focus on GvHD and immuno-oncology topics (he co-authored >700 peer-reviewed publications).
Master student (M2)
MD, Research Assistant
Marwa studied medicine from 2009 to 2019, she specialized in Pediatrics. She completed a Master 2 degree in St-Giles laboratory of human genetics of infectious diseases in New York. She joined the team in December 2020 to work on Castleman disease.
- Idan MILO, Postdoc
- Aurélien GIBAUD, Technician
- Ghada BEN-YOUSEF, Experimental Engineer
- Viviane GOURNAY, Master student (M2)
- Matthieu JESTIN, Master student (M2)
- Anthony VANJAK, Master student (M2)
- Margaux GARZARO, Master student (M2)
- Maxime ENAULT, Master student (M2)
- Deborah MEYRAN, PhD student
- Robin BERNARD-BLOCH, Technician