Our team has identified vesicles produced by poorly metastatic cells capable of blocking tumor growth and the appearance of metastases in a model of breast cancer. Besides breast cancer, these vesicles also have an anti-tumor power on pancreatic cancer, melanoma and glioblastoma (1). The project funded by Gefluc aims to identify which factors, present within these vesicles, are decisive in limiting tumor progression and the appearance of metastases with a view to developing new effective therapies to treat aggressive cancers.

(1) Camargo, L. C. B. de et al. Extracellular vesicles produced by NFAT3-expressing cells hinder tumor growth and metastatic dissemination. Sci Rep 10, 8964 (2020).